Part 4: Extracted from the White Paper "Secreted Matrix™ and Matrix NC-138™" by Michael Cohen
Material and methods
An O/W emulsion containing 3.0% Matrix NC-138™ has been tested on 12
volunteers against a placebo in a half-face double blind study. Volunteers were
asked to apply the cream twice daily for 6 weeks on the crow feet area. Several
parameters were analyzed after this period of time: skin profile (with PRIMOS
device), skin hydration with a corneometer and a self assessment on the product
given by panelists through a questionnaire.
Results
Matrix NC-138™ reduces wrinkles. After 6 weeks, this wrinkle reduction is highly
significant compared to baseline (p < 0.001). Regarding subtle wrinkles, Matrix
NC-138™ shows better results than a placebo. After 6 weeks treatment, the
decrease of subtle wrinkle depth is significant compared to baseline. For the
placebo, there is no effect after 6 weeks. Therefore Matrix NC-138™ leads to a
refinement of the skin texture and contributes to a youthful look. Additionally,
Matrix NC-138™ increases moisture content of the skin. One of the clinical
manifestations of skin aging is xerosis (dry skin). Matrix NC-138™ helps to
counteract this decrease of moisture retention and gives suppleness to the skin.
The moisture content was clearly improved compared to placebo control after 4
weeks of application. (Figure 4)"PROTEODERM and MATRIX NC-138 are trademarks of Proteoderm, Inc. and  is a trademark of Proteonomix, Inc."
Figure 4
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