Part 3: Extracted from the White Paper "Secreted Matrix™ and Matrix NC-138™" by Michael Cohen
Material and methods
Fibroblasts and keratinocytes from 63 years old donor were incubated 96 hours
with either Matrix NC-138™ or a positive control (transforming growth factor
beta-1 = TGF- B1).
Stimulation of collagen production was measured by immuno labelling
fluorescence assay.
Results
Matrix NC-138™ induced very effectively collagen production by more than
300% in aged, senescent fibroblasts.
(Figure 2). With only 1.00% Matrix NC-138™, collagen is induced 2.1 fold over
the control. The highest induction levels were observed using 2.00% (3.2 fold) or
3.00% (5.5 fold) Matrix NC-138™.
"PROTEODERM and MATRIX NC-138 are trademarks of Proteoderm, Inc. and  is a trademark of Proteonomix, Inc."
Figure 2
In addition it was demonstrated that Matrix NC-138™ rejuvenates skin cells
(keratinocytes and fibroblasts). Keratinocytes represent 90% of the epidermal cell
population and, with time, they lose their proliferative capacity and their longevity.
This leads to reduced skin renewal and slow healing of minor injuries. Fibroblasts
are the main cells of the dermis. They are responsible for the synthesis of many
tissue proteins, like collagens which are integral building blocks of the dermal
matrix. The dermal collagen network keeps skin elastic, supple and wrinkle-free.
The dermal network which contributes to skin firmness, elasticity and
smoothness breaks down with age and becomes disorganized, leading to
wrinkles. As it is shown on Figure 3, Matrix NC-138™ extended the longevity of
keratinocytes and fibroblasts and thereby helps the skin fight against the signs of
aging.
Figure 3
Click Here for Part 4: In Vivo Studies |
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